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Across the wider body of data, alopecia is classed as a common event, meaning at least one in a hundred people treated, at 2.5% versus 1.0% on placebo
Interestingly, the influence on RAAS should also be considered in the clinical practice during the screening of suspected hyperaldosteronism due to the interfering regulation of sodium and water balance or mimicking the effects of beta-blockers (SGLT2-i)
Animal studies identified thyroid C-cell tumours in rodents, but relevance to humans remains unknown
These are often temporary and can be managed with dose adjustments
GLP-1 receptor activation also exerts cardioprotective effects, including improved endothelial function, reduced inflammation, and modest reductions in blood pressure and cholesterol levels
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